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About SoLA® Technology
SoLA® Technology leverages a material that mimics cell membrane-like structures, forming covalent bonds with high-density materials and cross-linkers through a thermal reaction on the surface of medical devices. It enhances biocompatibility, stability, hydrophilicity, and anti-biofouling properties, effectively reducing inflammatory and immune responses in the human body when devices are implanted in human body.
Optimal Biocompatibility
PMPC (Poly 2-methacryloyloxyethyl phosphorylcholine) is zwitterionic polymer structurally analogous to the head group of phosphatidylcholine present in cell membranes, demonstrates a pronounced inhibitory effect on the nonspecific adhesion of proteins and fibroblasts to implant surfaces. Moreover, surfaces functionalized with MPC-based polymers exhibited substantial resistance to bacterial adhesion and proliferation, making them potential candidates for mitigating infection and inflammation associated with bacterial activity.
Enhanced Hydrophilicity
The covalent attachment of MPC polymer chains to silicone substrates alters the surface properties from hydrophobic to hydrophilic in both PMPC-silicone and SoLA® Technology-silicone systems. Notably, surfaces with enhanced hydrophilicity were significantly observed when SoLA® Technology was employed on the surface.
Enhanced Stability
During the initial stages of polymerization, SoLA® Technology facilitates the formation of a high-density network of polymer chains on the silicone surface. As polymerization proceeds, it contributes to the establishment of a stable MPC network.
Anti-Biofouling Effect
Remarkably, SoLA® Technology applied silicone surfaces demonstrated a significant reduction in bacterial adhesion, with a 99% and 95% decrease in adherence for S. epidermidis and R. pickettii, respectively, compared to bare surfaces. These findings strongly indicate that the application of SoLA® Technology is highly effective in preventing bacterial colonization on silicone surfaces. Consequently, silicone implants could benefit from enhanced resistance to bacterial contamination, significantly reducing the risk of infection.